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DC-SIGNR polymorphisms and the association with HIV-1 infection within the Chinese population
Presented by Hui Wang, China.
Wang H.1, Wang C.2, Xiao X.3, Feng T.4, Zhou H.5, Liu F.6, Zhu T.7, Zhou B.1
1Shenzhen Municipal Hospital of Infectious Dieases, Department of AIDS Clinical Research, Shenzhen, China, 2University of Washington School of Medicine, Departmemt of Laboratory Medicine, Seattle, United States, 3Jinan University, Center for HIV Genomics and Vaccines, Guangzhou, China, 4Shenzhen Municipal Center for Disease Control and Prevention, Shenzhen, China, 5Shenzhen STD Control Center, Shenzhen, China, 6Dongguan Blood center, Dongguan, China, 7University of Washington School of Medicine, Seattle, United States
Objectives: The C-type lectin DC-SIGNR has been shown to bind HIV-1 human immunodeficiency virus type 1 (HIV-1). A number of studies on the association between DC-SIGNR genotype and susceptibility of HIV-1 have reported mixed results.
Methods: we studied the variants of DC-SIGNR in the Chinese Han population, and further examined their association with HIV-1 infection among 1333 individuals- 520 healthy subjects, 345 HIV-1 seropositive individuals and 468 high risk HIV-1 seronegative individuals.
Results: We found 18 genotypes and 6 alleles in DC-SIGNR repeat regions within the Chinese population, which distribution was different from the Caucasions, the most common genotype of DC-SIGNR among the Chinese Han population is also 7/7 but with a higher frequency than in Caucasians (41.81% vs.31.09%, p<0.001); HIV-positive individuals in the Chinese Han population had a lower frequency of 7/7 genotype than the high-risk seronegative indivlduals (38.55% vs. 48.29%, p=0.0057); but a higher frequency of 9/5 (4.25% vs. 1.07%, p=0.0029).
Conclusions: The results suggested that the polymorphisms of the DC-SIGNR repeat regions in the Chinese Han population exhibit unique genetic characteristics previously unrecognized in the Caucasian population; and genotype 9/5 seems to be more susceptible to HIV-1 in the Chinese population.
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